Glioblastoma (No. 2)
World Council for Health Interviews Thomas Seyfried, PhD and Paul Marik, MD. Glioblastoma Referenced
The Seyfried & Marik Interview
The World Council for Health held their General Assembly in July, 2023. Thomas Seyfried, PhD, Professor at Boston College and Keto for Cancer and Paul Marik, MD, of FLCCC Alliance, joined The Council’s staff in this excellent discussion on the topic of diet and repurposed drugs in cancer treatment.1
I was surprised when glioblastoma was used as the example…three times! Both doctors support integrative strategies that combine conventional care with dietary intervention and repurposed drugs. However, Dr. Seyfried makes a dramatic statement about GBM and Radiation Therapy around 14:45.
I recommend watching the full interview, titled Cancer Treatment: The Role of Diet & Repurposed Drugs, in its entirety. You be left with a better understanding of cancer — what is happening from a physiological viewpoint — and why conventional treatment is associated with mortality for many types of tumors, especially brain cancer, specifically glioblastoma tumors.
Where to go for more information
Dr. Seyfried’s website is Keto for Cancer.
Dr. Marik’s new book and slide presentations: Cancer Care: The Role of Repurposed Drugs and Metabolic Inerventions in Treating Cancer
I am currently reading this book and am writing a summary of recommendations for GBM.
Outline of the full interview; approximate time stamps provided; references to glioblastoma are in bold
[2:00] How does cancer start? How to manage cancer? Somatic mutation theory is the predominant view. Cancer is a mitrochondrial/metabolic disorder - based on work of Otto Warburg (energy shifts from oxygen-derived to fermentation) ; Ca cells do not need oxygen
[4:00] Causes - radiation, carcinogens, hypoxia, inflammation, rare inherited mutations (risk factors); current crisis - treatments are midieval and not related to biology of the problem; cells falls back on default state: dysregulated cell growth driven by a fermentation metabolism b/c the oxidation-phosphorylation system is defective. Metastasis is driven by corrupted immune system
[7:00] What fuels cancer cell growth? Two synergistic fuels. How to control cancer? Transition to fatty acids and ketone bodies. Press-Pulse Therapeutic Strategy. Future of cancer management [T note - no talk of recovery or cure]
[9:15] Press-pulse is a framework. I’m a researcher, not a physician. Humans respond really well. Dogs respond really well. We evolved as a ‘starved’ species.
[11:00] Glucose and ketone management is not easy. Patient plays a major role in management of their disease. Ketogenic diet? Glucose - ketone index calculator - 2.0 or below - What does a food to do your index? Use a quantitative biomarker. Glutamine is the most abundant amino acid in the body. Dosing/timing/scheduling to pulse glutamine targets; too aggressive will be harmful; target glutamine and glucose simultaneously.
[13:45] Chemo and radiation - do they have a place? Didn’t answer the question. “Those chemicals can still be used.
[14:45] Radiation raises blood sugar levels. Radiation should never be used in brain tumors, b/c it frees up glucose and glutamine in the tumor’s environment, leading to rapid demise and death of the patient
[16:00] Causes of disease / causative agents? “Difficult to get cancer if tissues remain healthy”. Explosion of Ca is due to lifestyle, intermittent hypoxia, carcinogens; secondary provocative effects (risk factors) - diet and lifestyle, largely from the environment. - to parse out what caused a cancer in one person in another … must have had damage to the cells … goes back to prevention —- keep mitochondria healthy
[19:00] What would you do? Dramatically change food pyramid. Exercise is essential. Available of processed foods. Identify health risk of these things. Education would need to come from government. ‘Avoid obesity.’ “Either they don’t care or they don’t know.” Give them info and let them make their own choices
[21:00] Applied kinesiology? Neither doctors could speak to this topic. “Chemicals in the environment - acute problem today.” “The business of America is business.” It’s the culture. That’s the way it is. “I like to stick to the science that is the underlying problem.”
[25:00] Biological dentists, environmental doctors, glucose management, whole food plant based (Dr. Cambell) ph control and inflammatory control w/ D3 and curcumin. Salt management? (Guerson and Schwitzer — too much sodium) intercellular potassium is too low
[27:00] High Na, low K is pro-inflammatory. Out of area of knowledge (Marik) Seyfried also could not answer. Switched topic to Mabendazole paper - powerful repurposed drug. Marik - in vitro and animal models; not a lot of clinical papers. If you’ve treated thousands of patients, then where is your case series? Both agree - Synergistic interaction b/w repurposed drugs and dietary factors. Trials are completely inappropriate. Compare to historical controls! Reasonable. RCT - unethical.
[32:30] Glioblastoma; Data that sugar soda drinks, or fruit juice alone can cause cancer. 80% of Americans aren’t eating real food
[34:30] Are people dying unnecessarily? Yes, oncologists are telling patients it doesn’t matter what they eat. Hyper-progressive disease from immunotherapy - for $200,000 the treatment can kill 20% ; RT costs $500,000 per patient. [T - confirm this] Demographic shift as we go forward.
[40:30] Increase of turbo cancer? Stage 4 is turbo — life threatening, still driven by fermentation. Marik - yes, aware of aggressive tumors; spike protein … [T Note - military data don’t consider changes to electromagnetic changes on and off bases]
[43:00] There are never long term studies. How can fundamental problem in system be changed? Marik - RCT doesn’t replicate real world practice and should be ditched. FDA should change focus to longitudinal studies. Pharma ‘games’ the results. RCT is a sham. Move toward real world prospective studies. Seyfried - Education is important here. Today’s patient fears the treatment. So patients need to make the change. The more $ you raise for Ca, the more Ca we’re going to get. Historical controls are the way to go.
[48:00] Ketogenic cancer for all cancer? Yes, can manage without toxicity. Elevate ketons and lower glucose, used w/ repurposed drugs to MANAGE. I didn’t say cure.
[49:30] What’s the best thing to do? Marik: Empower patient, educate patients. AND the reverse — patients need to educate their physicians. Seyfried: Fall back on the science - the pathways, the evidence ; have the science to support what you’re saying; comprehensive treatment protocol for Glioblastoma.